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光甘草定

分析標(biāo)準(zhǔn)品,HPLC≥98%

Glabridin

CAS號(hào)：59870-68-7

分子式：C20H20O4

分子量：324.37

MDL：MFCD03427694

產(chǎn)品介紹

Glabridin 能夠結(jié)合并激活PPARγ，EC50值為 6115 nM，是一種從Glycyrrhiza glabra中分到的異黃烷類天然產(chǎn)物。它具有抗炎、抗菌、抗腎炎、抗氧化、抗腫瘤、抗糖尿病、抗骨質(zhì)疏松、保護(hù)神經(jīng)、保護(hù)心血管、清除自由基等作用。

熔點(diǎn)：154-155℃

沸點(diǎn)：518.6℃at 760 mmHg

比旋光度：(c, 2.07 in CHCl3)+8.2

外觀：淡黃色粉末

溶解性：DMSO  :  25  mg/mL  (77.07  mM;  Need  ultrasonic)

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(18篇)

18. [IF=2] Jingwu Song et al."Epigallocatechin-3-Gallate and Glabridin Synergistically Inhibited Melanogenesis by Molecular Interaction and the MicroRNA–Microphthalmia-Related Transcription Factor Pathway."JOURNAL OF MEDICINAL FOOD.

17. [IF=5.4] Jianzeng Liu et al."Glycyrrhiza glabra Extract as a Skin-whitening Agent: Identification of Active Components and CRTC1/MITF Pathway-Inhibition Mechanism."JOURNAL OF ETHNOPHARMACOLOGY.2025 May;:119948

16. [IF=8.5] Muhammad Tariq et al."Nano-encapsulation of Glabridin using enzymatically hydrolyzed sodium caseinate for improved bioavailability and functional applications."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jun;315:144541

15. [IF=6.7] Yushu Wang et al."Honey-fried licorice in the treatment of arrhythmia: structure elucidation and the mechanism of antiarrhythmic activity."PHYTOMEDICINE.2024 Nov;:156259

14. [IF=3.7] Zhaofeng Guan et al."Deep-eutectic solvent extraction of ginsenosides and ginseng polysaccharides from ginseng residue and utilization of post-extraction residue."PROCESS BIOCHEMISTRY.2025 Feb;149:99

13. [IF=4.9] Yang Zhang et al."Characterization and identification of chemical components in Si-Ni-San based on UPLC-Q-Orbitrap-MS, HS-SPME-GC–MS, and HS-GC-IMS techniques."MICROCHEMICAL JOURNAL.2025 Feb;209:112718

12. [IF=6.7] Zheng-Meng Jiang et al."Glycyrrhetinic acid ameliorates gastric mucosal injury by modulating gut microbiota and its metabolites via Thbs1/PI3K-Akt/p53 pathway."PHYTOMEDICINE.2025 Apr;:156745

11. [IF=4.9] Zhang Min et al."Discovery and evaluation of active compounds from Xuanfei Baidu formula against COVID-19 via SARS-CoV-2 Mpro."Chinese Medicine.2023 Dec;18(1):1-14

10. [IF=7.31] Tingting Li et al."Investigation of the Effects of Glabridin on the Proliferation, Apoptosis, and Migration of the Human Colon Cancer Cell Lines SW480 and SW620 and Its Mechanism Based on Reverse Virtual Screening and Proteomics."Oxidative Medicine and Ce

9. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

8. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

7. [IF=4.36] Qingquan Guo et al."Glabrol impurity exacerbates glabridin toxicity in zebrafish embryos by increasing myofibril disorganization."J Ethnopharmacol. 2022 Apr;287:114963

6. [IF=1.885] Xia Wenxin et al."Study on the Spectrum-Effect Relationship of the Traditional Effect of Saponins in Glycyrrhiza uralensis Fisch."Int J Anal Chem. 2021;2021:6617033

5. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826

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3.  楊小平  鄒多兵  丁延輝 等. 光甘草定對(duì)結(jié)直腸癌細(xì)胞RKO增殖和凋亡的影響[J]. 安徽醫(yī)科大學(xué)學(xué)報(bào)  2017(1).

2.  黃尚校、李春君、黃劍鋒、莫敦昌、羅鵬輝、王寒蕾. 光甘草定對(duì)宮頸癌Hela細(xì)胞增殖 侵襲和凋亡的影響及其機(jī)制[J]. 現(xiàn)代腫瘤醫(yī)學(xué)  2020  v.28;No.301(19):16-20.

1.  朱子博  樊金玲  程源斌 等. 光果甘草提酸廢渣萃取物降血糖活性的研究[J]. 食品科技  2019  v.44;No.332(06):238-246.